MICROECOLOGICSSANYI GROUP - Product Center - MICROECOLOGICS

Probiotics

Intestinal health care, treatment and growth promotion

Definition of probiotics

Probiotics are biological agents or substances promoting the growth of host beneficial bacteria. By the principles of microecology, probiotics are made from beneficial microorganisms and their metabolites which are separated, identified or artificially constructed through bioengineering from animals or nature and made by special processes such as culture, fermentation, drying and processing, and are used to improve the health level of human, livestock and poultry host or plant host.

1. KC070 (Mixed feed additive Bacillus subtilis)

Passing bacteria, aerobic, mainly act on the middle and front part of the small intestine. The metabolites mainly include amylase, lipase, protease, cellulase, pectinase, xylanase and other digestive enzymes. It can improve the digestibility of animal nutrients, and also has a certain antibacterial effect, improves the micro-ecological environment, effectively maintains the health of livestock and poultry, and improves animals immunity, disease resistance and stress resistance.

Raw materials composition:

Bacillus subtilis，glucose-based carrier.

Strain characteristics：

① The strain has strong vitality, fast propagation, strong adaptability, heat resistance, and can withstand high temperature granulation. Resisting the attack from gastric acid and bile salt, it can smoothly pass through the stomach into the duodenum, and multiply in the small intestine.

② It has superior enzyme production performance and large enzyme production, the average enzyme production is 4-6 times that of the general strain, especially in producing xylanase, cellulase, amylase, protease, etc.

③ After the coating process, the activity of the organic acids and vitamins produced during the fermentation process is well preserved.

Product Performances：

① Regulate the intestinal microecological balance：Bacillus subtilis can rapidly consume free oxygen in the environment, promote the growth of anaerobic probiotics (lactic acid bacteria, clostridium butyricum, bifidobacterium, etc.), and produce lactic acid and other organic acids and antibacterial substances such as subtilisin, polycolistin, nystatin, breitracin, inhibit the growth and reproduction of intestinal pathogenic bacteria. Significantly reduce the number of intestinal escherichia coli, clostridium perfringens, salmonella and other harmful bacteria, maintain intestinal ecological balance, effectively prevent diarrhea (dysentery), constipation, enhance anti-stress ability, reduce the occurrence of diseases.

② Produce a variety of enzymes: Bacillus subtilis can secrete a variety of enzymes (cellulase, xylanase, amylase, protease, etc.), which work together with endogenous enzymes in the digestive tract to increase animal digestive enzyme activity and improve feed utilization rate.

③ Produce a variety of nutrients: Bacillus subtilis grows and reproduces in the intestines of animals, can produce vitamins, amino acids, growth-promoting factors and  other nutrients, improve feed conversion rate, promote the growth of livestock and poultry, and can also improve the utilization rate of calcium and phosphorus and participate in the metabolism of the body.

④ Improve animal immunity: Bacillus subtilis can stimulate the growth and development of animal immune organs, activate lymphocytes, improve immunoglobulin and antibody levels, activate the immune defense system of the whole body through lymphatic circulation, and improve animal immunity.

⑤ Improve feed digestion and absorption rate, reduce feeding cost, improve meat quality; Reduce morbidity, increase survival rate, promote growth and improve daily gain.

⑥ Effectively improve aquaculture water, obviously reduce the incidence of aquatic animal diseases caused by deterioration of water quality.

⑦ Optimize the ecological environment, reduce the concentration of harmful gases such as ammonia and hydrogen sulfide in the animal house, reduce the excretion of organic matter in the feces, and reduce the incidence of respiratory diseases.

⑧ The spores have good stability and can be used synergistically with antibiotics to effectively reduce the amount of antibiotics and prevent drug resistance.

2. Y038 (Mixed feed additive Bacillus licheniformis)

Passing bacteria, facultative anaerobic, can act on the whole intestinal tract, metabolites mainly include amino acids, vitamins, a variety of digestive enzymes and enzyme stimulating factors. It has good bacteriostasis and enzyme production effect, can adjust the intestinal flora balance of animals, improve the micro-ecological environment, effectively maintain the health state of livestock and poultry, improve animals’ immunity, disease resistance and anti-stress ability. Reducing the amount of antibiotics, natural, economical and green.

Raw materials composition:

Bacillus licheniformis，glucose-based carrier.

Strain characteristics:

① Clear functions, stable variety quality, and remarkable application effect;

② Mainly spore morphology, good stability, high temperature resistance and extrusion resistance;

③ Fast reproductive ability, strong enzyme production ability, easy to survive, and tolerate low pH environment;

④ Reanimate quickly and form a dominant population with high bacterial content in a short time.

⑤ Safe, efficient, non-resistant, environmentally friendly.

Product Performances：

① Antagonize animal pathogenic bacteria, maintain and regulate intestinal microecological balance：Bacillus licheniformis are aerobic bacteria. After entering the intestinal tract, it has a biological oxygen absorption effect, which can promote the growth of beneficial intestinal bacteria such as bifidobacteria and lactobacillus, inhibit the growth and reproduction of most aerobic pathogenic bacteria. In the process of growth and metabolism, it can produce gramicidin, subtilisin, nystatin and other antibacterial substances which have a strong antagonistic effect on Staphylococcus and Salmonella, maintain the intestinal microecological balance, and make diarrhea and other symptoms relieve or disappear..

② Produce a variety of enzymes and improve animal digestive enzyme activity：Bacillus licheniformis can produce a variety of active enzymes, such as protease, amylase, lipase, pectinase, glucanase, cellulase, etc. It can also produce a variety of enzymatic factors to enhance the activity of animal digestive enzymes. Promote the growth of farmed animals and improve feed utilization.

③ Improve immunity: Enhance the body's specific and non-specific immune response, promote the phagocytic activity of macrophages, improve the ability to resist infection, and have obvious effects on mild or severe acute enteritis, mild and common acute bacillary dysentery, etc.

④ To replace antibiotics added in feed, it is an essential product for the production of drug-free residual animal products.

⑤ Used in aquaculture to purify water quality.

3. N0159 (Mixed feed additive Bacillus coagulans)

Passing bacteria, facultative anaerobic, can act on the whole intestinal tract, metabolites mainly include lactic acid, amino acids, vitamins and a variety of digestive enzymes. Bacillus coagulans is a lactic acid-producing bacillus. In addition to having the same health benefits as lactic acid bacteria (adjusting the intestinal flora) and Bacillus (high temperature resistant granulation), it also has resistances to heat, acid and bile salt, easily cultivated and preserved.

It is a safe and efficient feed additive approved by FDA of the United States.

Raw materials composition:

Bacillus coagulans，glucose-based carrier.

Strain characteristics:

① The strain has strong vitality, fast propagation, high spore yield, strong adaptability, heat resistance, and can withstand high temperature granulation. Resisting the attack from gastric acid and bile salt, it can smoothly pass through the stomach into the duodenum, and multiply in the small intestine.

② The drug susceptibility test confirmed that the product is not sensitive to amoxicillin and they can be used in combination, it is more sensitive to neomycin and florfenicol and they can not be used together.

Product Performances：

① Effectively inhibit the growth of harmful bacteria, improve the intestinal microecological environment, promote intestinal development, and enhance intestinal function. Bacillus coagulans is a type of facultative aerobic bacteria that consumes free oxygen after entering the intestines and reproduces, which is beneficial to the growth of anaerobic microorganisms such as lactic acid bacteria and bifidobacteria, thereby regulating the intestinal micro-ecological flora balance and improving body immunity and disease resistance, reducing the occurrence of intestinal diseases. The produced lactic acid, antibacterial coagulin and various enzymes can inhibit the reproduction of harmful bacteria, have laxative and antidiarrheal effects, and have a certain therapeutic effect on gastrointestinal inflammation. Effectively improve animal dysbacterial diarrhea caused by stress and allergic reactions.

② Regulate the functions of the immune system and reduce the death rate.

③ Provide nutrients, promote body growth, improve feed quality, promote feed digestion and absorption, reduce feed to gain ratio. Bacillus coagulans reproduces in the intestines and secretes amylase and protease to help digest and absorb nutrients; the vitamins, amino acids, short-chain fatty acids and other substances it produces can supplement certain nutrients needed by the animal itself, accelerating the peristalsis speed of small intestine and improving intestinal digestion.

④ Reduce harmful gases such as ammonia and hydrogen sulfide in the environment and improve the breeding environment.

1.P076 (Mixed feed additive Enterococcus faecalis)

Common bacteria, facultative anaerobic, can act on the entire small intestine, metabolites mainly include lactic acid, propionic acid, vitamins, essential amino acids, intestinal mucosal repair factors, etc. It is an important lactic acid bacteria with good intestinal adhesion ability. It can inhibit the reproduction of intestinal spoilage bacteria and pathogenic bacteria, reduce intestinal infections, the diarrhea rate, promote the digestion and absorption of nutrients, increases feed intake and feed Conversion rate; enhance immunity and promote animal health. The effect is better when animal excrement contains feed, ammonia smell is strong and absorption of nutrients is poor.

Raw materials composition:

Enterococcus faecalis，glucose-based carrier.

Strain characteristics:

① Enterococcus faecalis can tolerate low pH and has high tolerance to gastric fluid, intestinal fluid and bile salt. It can successfully pass through the stomach to reach the intestine and colonize, and provide prerequisites for probiotics to work.

② As the normal dominant flora in the intestinal tract of animals, it has strong tolerance and colonization ability in the intestinal mucosa.

③ High temperature resistance, can withstand high temperature granulation.

④ Compared with bifidobacterium and lactobacillus which are strictly anaerobic and have harsh culture and preservation conditions, it is easy to produce and use.

Product Performances：

① Maintain digestive tract microecological balance：Enterococcus faecalis can multiply after colonization in the intestine. The organic acids such as lactic acid, acetic acid and isobutyric acid produced during the growth and reproduction process can adjust the pH value of the intestine. It also produces bacteriostatic metabolites such as bacteriocins, inhibits the growth of harmful microorganisms, regulates the intestinal microecological balance, and reduces the intestinal diseases occurrence.

② Provide nutrients, promote body growth：The L-type lactic acid secreted by Enterococcus faecalis after colonization in the intestine can enhance the digestion and absorption capacity of the intestine; Enterococcus faecalis can increase the activity of digestive enzymes such as protease, amylase, lipase and cellulase in the digestive tract of animals. These enzymes can promote the decomposition of protein, fat and complex carbohydrates in the feed, and the final monomer and energy can be supplied for body's growth and development, thereby improving the digestion and absorption rate of feed and promoting the growth of animals; Enterococcus faecalis can also produce vitamins, amino acids, growth-promoting factors and other nutrients during the growth and reproduction process, promoting the absorption of mineral elements such as iron, calcium, zinc, and supplementing the body's nutritional elements. In addition, Enterococcus faecalis can soften the fiber in the feed and improve the feed conversion rate.

③ Regulate immunity and improve disease resistance：Enterococcus faecalis can improve the animals immunity and enhance their ability to resist pathogen infection. Enterococcus faecalis can form biofilms attached to the intestinal mucosa of animals, and develop, grow and reproduce, forming a immune barrier of lactic acid bacteria to resist the invasion of foreign bacteria, viruses, mycotoxins and other harmful substances.

2.Q056 (Mixed feed additive Enterococcus faecium)

Common bacteria, facultative anaerobic, can act on the entire small intestine, metabolites mainly include lactic acid, bacteriocin, hydrogen peroxide, vitamins, amino acids, growth-promoting factors, etc. It plays an important role in maintaining the ecological balance of animal intestinal flora, and has outstanding performance in the intestinal health care of young animals and the prevention and treatment of diseases.

Raw materials composition:

Enterococcus faecium，glucose-based carrier.

Strain characteristics:

① Enterococcus faecium coated by a special process can tolerate the influence of gastric juice, intestinal juice, and bile salts, it can successfully pass through the stomach to reach the intestine and colonize, and provide prerequisites for probiotics to work.

② It is resistant to most commonly used antibiotics. In addition to antibiotic resistance, it also has a strong inhibitory effect on common pathogens and virulent strains.

③ Compared with bifidobacterium and lactobacillus which are strictly anaerobic and have harsh culture and preservation conditions, it is easy to produce and use.

Product Performances：

①Maintain the micro-ecological balance of the digestive tract: Enterococcus faecium can quickly adhere to the intestinal mucosa, inhibit pathogenic bacteria from adhering to the intestinal tract, form an intestinal barrier, maintain the micro-ecological balance, and protect intestinal health. The lactic acid, bacteriocin and hydrogen peroxide produced in the metabolic process can lower the pH of the intestine, inhibit the reproduction of animal pathogenic bacteria, maintain and adjust the intestinal microecological balance, reduce the content of toxins and urease in the intestine, reduce toxins in the blood and the content of ammonia, promote the maturity of animal organs, and improve the physiological state of animals.

② Provide nutrients, promote body growth: Produce a variety of nutrients (vitamins, amino acids, growth factors, etc.), nutrients can participate in metabolism, promote animal growth.

③ Regulate immunity and improve disease resistance: Induce the body to produce interferon, interleukin, etc. It can enhance the body's non-specific immune function, improve disease resistance, reduce inflammation, and promote intestinal health.

6. DS058 (Mixed feed additive Clostridium butyricum)

Common bacteria, anaerobic, mainly act on the posterior segment of intestinal mucosa, metabolites mainly include butyric acid, antimicrobial peptides, vitamins and digestive enzymes. They can help the animal intestine to digest and absorb nutrients for the second time, and inhibit the growth and reproduction of Salmonella, Clostridium weichii, Pasteurella, E. coli and other pathogenic bacteria. Therefore, they are used when animals’bacterial or nutritional diarrhea, unformed stool, constipation, necrotizing enteritis, colitis, and ileitis occurs. As a new type of live bacteria feed additive, Clostridium butyricum is the first choice for protecting intestinal health and improving production performance. The application of Clostridium butyricum is of great significance for reducing the use of antibiotics and drug residues in meat, as well as preventing the resistance of pathogens and ensuring the health of the animal's intestinal tract.

Raw materials composition:

Clostridium butyricum，glucose-based carrier.

Strain characteristics：

① Strong tolerance: Clostridium butyricum has strong tolerance to a variety of antibiotics (β-lactams, macrolides, quinolones, etc.). It can be used in combination with certain antibiotics and has a synergistic effect,and can alleviate the side effects of antibiotics;

② Good stress resistance: Clostridium butyricum belongs to the genus Bacillus, can withstand high temperature (all survive at 90℃ for 10 minutes, 100℃ for 5 minutes), can be used to manufacture granular materials. Can tolerate stomach acid, digestive enzyme and bile acid, its effect is more accurate.

③ Good adaptability：Clostridium butyricum is a strict anaerobic bacterium that is fully adapted to the anaerobic environment of animal intestines. It is a common bacterium in animal intestines. It can pass through the stomach and small intestine and reach the fully anaerobic ileocecal junction, cecum and colon for colonization,  reproduction and metabolism.

④ Strong adhesion ability: The prerequisite for clostridium butyricum colonization in the intestine and the key to its long-lasting probiotic effect is its strong adhesion ability, preventing the invasion and colonization of harmful bacteria, and ensuring the intestinal microecological balance.

⑤ Resistance reduction and replacement: Clostridium butyricum, as a new type of live bacteria feed additive, is conducive to reducing the abuse of antibiotics, reducing drug residues and emissions, preventing drug resistance, and ensuring animal health.

Product Performances：

① Regulate the balance of intestinal flora and reduce the occurrence of constipation, diarrhea, dysentery, etc.: Clostridium butyricum can promote the proliferation and development of beneficial flora (Bifidobacterium, Lactobacillus) in animal intestines, and can ferment sugars to form a large amount of short-chain fatty acids such as butyric acid, acetic acid and lactic acid which can maintain an acidic environment, lower the pH of the intestine, inhibit the growth and reproduction of harmful bacteria and spoilage bacteria in the intestine, correct the disorder of the intestinal flora, reduce the occurrence of intestinal toxins, and greatly reduce the rate of diarrhea. Its main metabolite is biobutyric acid, which is the main nutrient for the regeneration and repair of intestinal epithelial tissue cells. It has a unique role in preventing and treating enteritis and promoting secondary digestion. Butyric acid-producing bacteria are more beneficial to the intestinal tract health than lactic acid-producing bacteria.

② Enhance immunity and anti-stress ability, reduce mortality rate, increase uniformity. Clostridium butyricum can increase the content of IgG and IgM in serum, and has a tendency to increase the content of serum IgA. Clostridium butyricum can increase the content of IgG and IgM in serum, and has a tendency to increase the content of serum lgA. Butyric acid produced in the intestine is the main energy source of intestinal mucosal cells, and has the function of repairing the intestinal mucosa and increasing the reversal of the permeability of the mucosa.

③ Significantly improve growth performance, promote growth, and increase feed conversion rate. The α-amylase, β-amylase, protease and lipase produced by Clostridium butyricum can promote the digestion and absorption of polysaccharide, protein and fat in animals. Pectinase, cellulase and glucanase can effectively degrade anti-nutrient factors in feed and improve feed utilization rate. It can synthesize and produce B vitamins, folic acid, niacin, VK, VE, etc., provide necessary nutrients for animals, and have health care effect.

④ Improve manure, reduce ammonia emissions and improve the feeding environment.

Cooperating with normal intestinal bacteria, it reduces the conversion of protein to ammonia and amines, reduces the production of harmful substances such as nitrosamine, indole and skatole, eliminates foul odors, and purifies the air quality in the house.

7. R074 (Mixed feed additive Enterococcus faecalis, Bacillus subtilis)

Raw materials composition

Enterococcus faecalis, Bacillus subtilis and their metabolites.，glucose-based carrier.

Product Performances

（1）Help digestion of feed, prevent the presence of feed in animal feces.

（2）Promote nutrient absorption and improve animal production performance;

（3）Reduce the concentration of toxic and harmful gases such as ammonia and reduce the excretion of feces;

（4）Spores consume oxygen and reduce the occurrence rate of coccidia;

（5）Balance intestinal flora, promote water absorption and feces formation;

（6）Reduce the use of drugs and improve the quality of meat and eggs.

8. DK122 (mixed feed additives Clostridium butyricum, Bacillus subtilis, Enterococcus faecalis)

Raw materials composition

Clostridium butyricum, Bacillus subtilis, Enterococcus faecalis and their metabolites.

Product Performances

（1）Prevent and control bacterial diseases such as Salmonella, Clostridium weichii, Escherichia coli, etc., treat intestinal inflammation, can be used when animals’bacterial or nutritional diarrhea, unformed stool, constipation, necrotizing enteritis, colitis, and ileitis occurs.

（2）Produce a variety of digestive enzymes, promote feed digestion and absorption, improve feed reward, reduce feed meat (egg) ratio;

（3）Produce butyric acid, can quickly repair the damaged intestinal mucosa, promote the development of immune organs and intestinal mucosa, improve the body mucosal immunity;

（4）Produce beneficial substances and promote the absorption of VE which can be absorbed and used by the body;

（5）Reduce the ammonia concentration of livestock and poultry houses, reduce the odor and improve the breeding environment.